L49Q (p.Leu49Gln) variant of TLR3 (Toll-like receptor 3)
L49Q (p.Leu49Gln) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.60 / 1. The record also includes population frequency data and structural context.
L49Q (p.Leu49Gln) variant details
- p.Leu49Gln
- TOPMed rs1489675622
- gnomAD rs1489675622
- Missense
- Variant Prioritization Score for Impact Estimate 0.602
- REVEL 0.63
- MetaLR 0.45
- MetaSVM 0.20
- CADD 24.70
- SIFT 0.00
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available