L49P (p.Leu49Pro) variant of TLR3 (Toll-like receptor 3)
L49P (p.Leu49Pro) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.64 / 1. The record also includes population frequency data, published literature, and structural context.
L49P (p.Leu49Pro) variant details
- p.Leu49Pro
- gnomAD 4-186076765-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.637
- REVEL 0.69
- MetaLR 0.45
- MetaSVM 0.20
- CADD 25.00
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- Literature evidence available