L42F (p.Leu42Phe) variant of TLR3 (Toll-like receptor 3)
L42F (p.Leu42Phe) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data and structural context.
L42F (p.Leu42Phe) variant details
- p.Leu42Phe
- ExAC rs764017833
- TOPMed rs764017833
- gnomAD rs764017833
- Missense
- Variant Prioritization Score for Impact Estimate 0.464
- REVEL 0.53
- MetaLR 0.42
- MetaSVM -0.22
- CADD 22.50
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the South Asian population (allele frequency 3.5e-05)
- Structural context available