L40V (p.Leu40Val) variant of TLR3 (Toll-like receptor 3)
L40V (p.Leu40Val) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.19 / 1. The record also includes population frequency data, published literature, and structural context.
L40V (p.Leu40Val) variant details
- p.Leu40Val
- gnomAD 4-186076737-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.192
- REVEL 0.17
- MetaLR 0.12
- MetaSVM -0.99
- CADD 10.50
- PolyPhen-2 0.13
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available
- Literature evidence available