L40R (p.Leu40Arg) variant of TLR3 (Toll-like receptor 3)
L40R (p.Leu40Arg) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
L40R (p.Leu40Arg) variant details
- p.Leu40Arg
- gnomAD rs1356345714
- Missense
- Variant Prioritization Score for Impact Estimate 0.311
- REVEL 0.24
- MetaLR 0.04
- MetaSVM -1.06
- CADD 23.60
- PolyPhen-2 0.59
- SIFT 0.03
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available