L40P (p.Leu40Pro) variant of TLR3 (Toll-like receptor 3)
L40P (p.Leu40Pro) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, published literature, and structural context.
L40P (p.Leu40Pro) variant details
- p.Leu40Pro
- gnomAD 4-186076738-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.367
- REVEL 0.31
- MetaLR 0.22
- MetaSVM -0.62
- CADD 25.50
- PolyPhen-2 0.90
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 5.4e-06)
- Structural context available
- Literature evidence available