G12E (p.Gly12Glu) variant of TLR3 (Toll-like receptor 3)
G12E (p.Gly12Glu) in TLR3 (Toll-like receptor 3) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data, published literature, and structural context.
G12E (p.Gly12Glu) variant details
- p.Gly12Glu
- gnomAD 4-186076654-G-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.154
- REVEL 0.18
- MetaLR 0.07
- MetaSVM -1.03
- CADD 2.04
- PolyPhen-2 0.04
- SIFT 0.27
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available
- Literature evidence available