I59F (p.Ile59Phe) variant of THRB (Thyroid hormone receptor beta)
I59F (p.Ile59Phe) in THRB (Thyroid hormone receptor beta) is a missense change. Clinical records from EBI and UniProt describe it as benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.29 / 1. The record also includes population frequency data and structural context.
I59F (p.Ile59Phe) variant details
- p.Ile59Phe
- 1000Genomes rs141172732
- ESP rs141172732
- ExAC rs141172732
- TOPMed rs141172732
- Benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.295
- CADD 21.00
- PolyPhen-2 0.01
- SIFT 0.07
- EBI: Benign
- UniProt: Benign
- Population evidence available
- Structural context available