D77N (p.Asp77Asn) variant of THRB (Thyroid hormone receptor beta)
D77N (p.Asp77Asn) in THRB (Thyroid hormone receptor beta) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.51 / 1. The record also includes population frequency data and structural context.
D77N (p.Asp77Asn) variant details
- p.Asp77Asn
- rs549469339
- NCI-TCGA Cosmic COSV1007
- cosmic curated COSV10072
- 1000Genomes rs549469339
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.513
- CADD 23.10
- PolyPhen-2 0.03
- SIFT 0.05
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available