P63S (p.Pro63Ser) variant of TH (Tyrosine 3-monooxygenase)
P63S (p.Pro63Ser) in TH (Tyrosine 3-monooxygenase) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
P63S (p.Pro63Ser) variant details
- p.Pro63Ser
- rs1353124114
- NCI-TCGA Cosmic COSV6076
- cosmic curated COSV60767
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.751
- AlphaMissense 0.16
- MetaLR 0.96
- MetaSVM 1.10
- PolyPhen-2 0.99
- SIFT 0.01
- MutPred 0.24
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available