L3M (p.Leu3Met) variant of TG (Thyroglobulin)
L3M (p.Leu3Met) in TG (Thyroglobulin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.15 / 1. The record also includes population frequency data and structural context.
L3M (p.Leu3Met) variant details
- p.Leu3Met
- rs1256883610
- TOPMed rs1256883610
- gnomAD rs1256883610
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.152
- REVEL 0.03
- MetaLR 0.15
- MetaSVM -0.96
- CADD 17.00
- PolyPhen-2 0.08
- SIFT 0.06
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Latino/Admixed American population (allele frequency 6.6e-05)
- Structural context available