L10P (p.Leu10Pro) variant of TG (Thyroglobulin)
L10P (p.Leu10Pro) in TG (Thyroglobulin) is a missense change. Clinical records from ClinVar and UniProt describe it as likely benign in the context of not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.54 / 1. The record also includes population frequency data and structural context.
L10P (p.Leu10Pro) variant details
- p.Leu10Pro
- ESP rs376079122
- TOPMed rs376079122
- gnomAD rs376079122
- Likely benign
- not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.538
- REVEL 0.53
- MetaLR 0.39
- MetaSVM -0.23
- CADD 24.40
- PolyPhen-2 1.00
- SIFT 0.00
- ClinVar: Likely benign (not specified)
- UniProt: Likely benign
- Most common in the Non-Finnish European population (allele frequency 1.5e-05)
- Structural context available