D66Y (p.Asp66Tyr) variant of TG (Thyroglobulin)
D66Y (p.Asp66Tyr) in TG (Thyroglobulin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.26 / 1. The record also includes population frequency data, published literature, and structural context.
D66Y (p.Asp66Tyr) variant details
- p.Asp66Tyr
- gnomAD 8-132869748-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.255
- REVEL 0.20
- MetaLR 0.27
- MetaSVM -0.84
- CADD 22.60
- PolyPhen-2 0.90
- SIFT 0.01
- Most common in the Latino/Admixed American population (allele frequency 4.5e-05)
- Structural context available
- Literature evidence available