S15I (p.Ser15Ile) variant of TET2 (Methylcytosine dioxygenase TET2)
S15I (p.Ser15Ile) in TET2 (Methylcytosine dioxygenase TET2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
S15I (p.Ser15Ile) variant details
- p.Ser15Ile
- cosmic curated COSV54411
- Missense
- Variant Prioritization Score for Impact Estimate 0.385
- REVEL 0.36
- MetaLR 0.21
- MetaSVM -0.72
- CADD 25.60
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available