P23S (p.Pro23Ser) variant of TET2 (Methylcytosine dioxygenase TET2)
P23S (p.Pro23Ser) in TET2 (Methylcytosine dioxygenase TET2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.16 / 1. The record also includes population frequency data and structural context.
P23S (p.Pro23Ser) variant details
- p.Pro23Ser
- NCI-TCGA Cosmic COSV5440
- cosmic curated COSV54407
- Ensembl rs2110219448
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.155
- REVEL 0.04
- MetaLR 0.05
- MetaSVM -1.02
- CADD 12.00
- PolyPhen-2 0.01
- SIFT 0.55
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the East Asian population (allele frequency 2.5e-05)
- Structural context available