S74P (p.Ser74Pro) variant of TECTA (Alpha-tectorin)
S74P (p.Ser74Pro) in TECTA (Alpha-tectorin) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.75 / 1. The record also includes population frequency data and structural context.
S74P (p.Ser74Pro) variant details
- p.Ser74Pro
- ExAC rs746713225
- gnomAD rs746713225
- Missense
- Variant Prioritization Score for Impact Estimate 0.746
- REVEL 0.80
- MetaLR 0.73
- MetaSVM 0.67
- CADD 27.20
- PolyPhen-2 0.99
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.2e-05)
- Structural context available