F57L (p.Phe57Leu) variant of TECTA (Alpha-tectorin)
F57L (p.Phe57Leu) in TECTA (Alpha-tectorin) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.71 / 1. The record also includes population frequency data and structural context.
F57L (p.Phe57Leu) variant details
- p.Phe57Leu
- NCI-TCGA TCGA novel
- cosmic curated COSV50789
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.713
- REVEL 0.79
- MetaLR 0.64
- MetaSVM 0.38
- CADD 27.10
- PolyPhen-2 0.58
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available