T77K (p.Thr77Lys) variant of TBK1 (Q9UHD2)
T77K (p.Thr77Lys) in TBK1 (Q9UHD2) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
T77K (p.Thr77Lys) variant details
- p.Thr77Lys
- gnomAD 12-64464335-C-A
- Missense
- Variant Prioritization Score for Impact Estimate 0.318
- REVEL 0.10
- CADD 19.10
- PolyPhen-2 0.04
- SIFT 0.52
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available
- Literature evidence available