L59F (p.Leu59Phe) variant of TBK1 (Q9UHD2)
L59F (p.Leu59Phe) in TBK1 (Q9UHD2) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
L59F (p.Leu59Phe) variant details
- p.Leu59Phe
- NCI-TCGA Cosmic COSV1005
- NCI-TCGA Cosmic COSV5915
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.45
- REVEL 0.55
- CADD 23.50
- PolyPhen-2 1.00
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available