T21S (p.Thr21Ser) variant of SYK (Tyrosine-protein kinase SYK)
T21S (p.Thr21Ser) in SYK (Tyrosine-protein kinase SYK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.44 / 1. The record also includes population frequency data and structural context.
T21S (p.Thr21Ser) variant details
- p.Thr21Ser
- ExAC rs758018137
- gnomAD rs758018137
- Missense
- Variant Prioritization Score for Impact Estimate 0.436
- REVEL 0.20
- CADD 22.30
- PolyPhen-2 1.00
- SIFT 0.86
- Most common in the Latino/Admixed American population (allele frequency 2.4e-05)
- Structural context available