R22L (p.Arg22Leu) variant of SYK (Tyrosine-protein kinase SYK)
R22L (p.Arg22Leu) in SYK (Tyrosine-protein kinase SYK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.85 / 1. The record also includes population frequency data and structural context.
R22L (p.Arg22Leu) variant details
- p.Arg22Leu
- ESP rs140421546
- ExAC rs140421546
- TOPMed rs140421546
- gnomAD rs140421546
- Missense
- Variant Prioritization Score for Impact Estimate 0.847
- REVEL 0.95
- CADD 29.80
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 2.4e-05)
- Structural context available