P14L (p.Pro14Leu) variant of SYK (Tyrosine-protein kinase SYK)
P14L (p.Pro14Leu) in SYK (Tyrosine-protein kinase SYK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.32 / 1. The record also includes population frequency data, published literature, and structural context.
P14L (p.Pro14Leu) variant details
- p.Pro14Leu
- gnomAD 9-90843939-C-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.323
- REVEL 0.18
- CADD 23.10
- PolyPhen-2 0.02
- SIFT 0.01
- Most common in the African/African-American population (allele frequency 3.1e-05)
- Structural context available
- Literature evidence available