L40M (p.Leu40Met) variant of SYK (Tyrosine-protein kinase SYK)
L40M (p.Leu40Met) in SYK (Tyrosine-protein kinase SYK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.53 / 1. The record also includes population frequency data and structural context.
L40M (p.Leu40Met) variant details
- p.Leu40Met
- ExAC rs764046624
- gnomAD rs764046624
- Missense
- Variant Prioritization Score for Impact Estimate 0.53
- REVEL 0.58
- CADD 23.70
- PolyPhen-2 1.00
- SIFT 0.00
- Most common in the Latino/Admixed American population (allele frequency 6.5e-05)
- Structural context available