G33S (p.Gly33Ser) variant of SYK (Tyrosine-protein kinase SYK)
G33S (p.Gly33Ser) in SYK (Tyrosine-protein kinase SYK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.45 / 1. The record also includes population frequency data and structural context.
G33S (p.Gly33Ser) variant details
- p.Gly33Ser
- cosmic curated COSV65330
- ExAC rs201364101
- TOPMed rs201364101
- gnomAD rs201364101
- Missense
- Variant Prioritization Score for Impact Estimate 0.45
- REVEL 0.22
- CADD 24.40
- PolyPhen-2 0.86
- SIFT 0.11
- Most common in the Ashkenazi Jewish population (allele frequency 3.9e-05)
- Structural context available