G33D (p.Gly33Asp) variant of SYK (Tyrosine-protein kinase SYK)
G33D (p.Gly33Asp) in SYK (Tyrosine-protein kinase SYK) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.58 / 1. The record also includes population frequency data and structural context.
G33D (p.Gly33Asp) variant details
- p.Gly33Asp
- cosmic curated COSV65326
- ExAC rs766412303
- TOPMed rs766412303
- gnomAD rs766412303
- Missense
- Variant Prioritization Score for Impact Estimate 0.58
- REVEL 0.50
- CADD 27.50
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available