F26L (p.Phe26Leu) variant of SUFU (Suppressor of fused homolog)
F26L (p.Phe26Leu) in SUFU (Suppressor of fused homolog) is a missense change. Clinical records from EBI and UniProt describe it as likely benign. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
F26L (p.Phe26Leu) variant details
- p.Phe26Leu
- Ensembl rs2135597954
- Likely benign
- Missense
- Variant Prioritization Score for Impact Estimate 0.306
- REVEL 0.23
- AlphaMissense 0.63
- MetaLR 0.17
- MetaSVM -0.90
- CADD 20.60
- PolyPhen-2 0.00
- EBI: Likely benign
- UniProt: Likely benign
- Population evidence available
- Structural context available