E14K (p.Glu14Lys) variant of STK11 (Q15831)
E14K (p.Glu14Lys) in STK11 (Q15831) is a missense change. Clinical records from EBI and UniProt describe it as uncertain significance in the context of in cervical cancer. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes published literature and structural context.
E14K (p.Glu14Lys) variant details
- p.Glu14Lys
- rs2145404557
- cosmic curated COSV58828
- UniProt VAR 065627
- Ensembl rs2145404557
- Uncertain significance
- in cervical cancer
- Missense
- Variant Prioritization Score for Impact Estimate 0.369
- AlphaMissense 0.14
- MetaLR 0.18
- MetaSVM -0.83
- PolyPhen-2 0.72
- SIFT 0.03
- MutPred 0.34
- EBI: Variant of uncertain significance (in cervical cancer)
- UniProt: Uncertain significance (in cervical cancer)
- Structural context available
- Cited in: Mutations in the STK11 gene characterize minimal deviation adenocarcinoma of the uterine cervix. (PMID 12533684)