L146F (p.Leu146Phe) variant of STAT6 (P42226)
L146F (p.Leu146Phe) in STAT6 (P42226) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.
L146F (p.Leu146Phe) variant details
- p.Leu146Phe
- gnomAD rs1387979430
- Missense
- Variant Prioritization Score for Impact Estimate 0.216
- REVEL 0.08
- CADD 14.80
- PolyPhen-2 0.18
- SIFT 0.08
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available