T157A (p.Thr157Ala) variant of STAT4 (Q14765)
T157A (p.Thr157Ala) in STAT4 (Q14765) is a missense change. Clinical records from ClinVar, EBI, and UniProt describe it as uncertain significance in the context of not provided; not specified. The available variant effect predictions contribute to a CATVariant prioritization score of 0.31 / 1. The record also includes population frequency data and structural context.
T157A (p.Thr157Ala) variant details
- p.Thr157Ala
- rs372399682
- ClinGen CA62695630
- cosmic curated COSV10888
- ClinVar RCV003719629
- Uncertain significance
- not provided; not specified
- Missense
- Variant Prioritization Score for Impact Estimate 0.31
- REVEL 0.12
- MetaLR 0.14
- MetaSVM -0.95
- CADD 22.30
- PolyPhen-2 0.37
- SIFT 0.24
- ClinVar: Uncertain significance (not provided; not specified)
- EBI: Variant of uncertain significance
- UniProt: Uncertain significance
- Most common in the REMAINING population (allele frequency 6.7e-05)
- Structural context available