R141S (p.Arg141Ser) variant of STAT4 (Q14765)
R141S (p.Arg141Ser) in STAT4 (Q14765) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.39 / 1. The record also includes population frequency data and structural context.
R141S (p.Arg141Ser) variant details
- p.Arg141Ser
- NCI-TCGA TCGA novel
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.391
- REVEL 0.23
- MetaLR 0.17
- MetaSVM -0.69
- CADD 23.20
- PolyPhen-2 0.47
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9e-07)
- Structural context available