N107H (p.Asn107His) variant of STAT4 (Q14765)
N107H (p.Asn107His) in STAT4 (Q14765) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.33 / 1. The record also includes population frequency data and structural context.
N107H (p.Asn107His) variant details
- p.Asn107His
- rs1337434431
- NCI-TCGA Cosmic COSV6182
- cosmic curated COSV61829
- gnomAD rs1337434431
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.332
- REVEL 0.20
- AlphaMissense 0.09
- MetaLR 0.19
- MetaSVM -0.78
- CADD 23.40
- PolyPhen-2 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 1.2e-05)
- Structural context available