L90F (p.Leu90Phe) variant of STAT4 (Q14765)
L90F (p.Leu90Phe) in STAT4 (Q14765) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.49 / 1. The record also includes population frequency data and structural context.
L90F (p.Leu90Phe) variant details
- p.Leu90Phe
- NCI-TCGA Cosmic COSV6183
- cosmic curated COSV61830
- gnomAD rs1699466959
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.486
- REVEL 0.35
- MetaLR 0.26
- MetaSVM -0.70
- CADD 23.10
- PolyPhen-2 0.98
- SIFT 0.01
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the African/African-American population (allele frequency 2.4e-05)
- Structural context available