L79F (p.Leu79Phe) variant of STAT4 (Q14765)
L79F (p.Leu79Phe) in STAT4 (Q14765) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data and structural context.
L79F (p.Leu79Phe) variant details
- p.Leu79Phe
- rs1405872272
- NCI-TCGA Cosmic COSV1006
- cosmic curated COSV10063
- TOPMed rs1405872272
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.374
- REVEL 0.33
- MetaLR 0.32
- MetaSVM -0.72
- CADD 22.50
- PolyPhen-2 0.78
- SIFT 0.10
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available