L57F (p.Leu57Phe) variant of STAT4 (Q14765)
L57F (p.Leu57Phe) in STAT4 (Q14765) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.30 / 1. The record also includes population frequency data and structural context.
L57F (p.Leu57Phe) variant details
- p.Leu57Phe
- NCI-TCGA Cosmic COSV1006
- cosmic curated COSV10063
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.305
- REVEL 0.12
- MetaLR 0.04
- MetaSVM -1.02
- CADD 18.90
- PolyPhen-2 0.02
- SIFT 1.00
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available