K88N (p.Lys88Asn) variant of STAT4 (Q14765)
K88N (p.Lys88Asn) in STAT4 (Q14765) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.21 / 1. The record also includes population frequency data and structural context.
K88N (p.Lys88Asn) variant details
- p.Lys88Asn
- NCI-TCGA Cosmic COSV1006
- cosmic curated COSV10063
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.207
- REVEL 0.06
- MetaLR 0.08
- MetaSVM -0.93
- CADD 17.80
- PolyPhen-2 0.12
- SIFT 0.00
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available