K146R (p.Lys146Arg) variant of STAT4 (Q14765)
K146R (p.Lys146Arg) in STAT4 (Q14765) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.24 / 1. The record also includes population frequency data and structural context.
K146R (p.Lys146Arg) variant details
- p.Lys146Arg
- gnomAD rs1449256873
- Missense
- Variant Prioritization Score for Impact Estimate 0.241
- REVEL 0.10
- MetaLR 0.11
- MetaSVM -1.00
- CADD 21.80
- PolyPhen-2 0.02
- SIFT 0.66
- Most common in the REMAINING population (allele frequency 1.7e-05)
- Structural context available