I86L (p.Ile86Leu) variant of STAT4 (Q14765)
I86L (p.Ile86Leu) in STAT4 (Q14765) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.35 / 1. The record also includes population frequency data and structural context.
I86L (p.Ile86Leu) variant details
- p.Ile86Leu
- gnomAD rs1462946559
- Missense
- Variant Prioritization Score for Impact Estimate 0.348
- REVEL 0.21
- MetaLR 0.15
- MetaSVM -0.89
- CADD 21.60
- PolyPhen-2 0.01
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 9.2e-07)
- Structural context available