Y34F (p.Tyr34Phe) variant of STAT2 (P52630)

Name: STAT2 Y34F (p.Tyr34Phe) variant | CATVariant
Creator: Center for Precision Medicine and Data Sciences
Published: 2026-08-20
License: https://catvariant.com/terms-of-use

Y34F (p.Tyr34Phe) in STAT2 (P52630) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.22 / 1. The record also includes population frequency data and structural context.

Y34F (p.Tyr34Phe) variant details

p.Tyr34Phe
NCI-TCGA TCGA novel
Variant assessed as somatic; moderate impact.
Missense
Variant Prioritization Score for Impact Estimate 0.225
REVEL 0.08
CADD 20.20
PolyPhen-2 0.04
SIFT 0.05
UniProt: Variant assessed as somatic; moderate impact.
Most common in the Finnish in Finland (FIN) population (allele frequency 1.9e-05)
Structural context available