M155T (p.Met155Thr) variant of STAT2 (P52630)
M155T (p.Met155Thr) in STAT2 (P52630) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.18 / 1. The record also includes population frequency data and structural context.
M155T (p.Met155Thr) variant details
- p.Met155Thr
- rs767217369
- NCI-TCGA Cosmic COSV5847
- cosmic curated COSV58475
- ExAC rs767217369
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.176
- REVEL 0.03
- CADD 7.72
- PolyPhen-2 0.01
- SIFT 0.58
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 2.7e-06)
- Structural context available