T37S (p.Thr37Ser) variant of SRC (P12931)
T37S (p.Thr37Ser) in SRC (P12931) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
T37S (p.Thr37Ser) variant details
- p.Thr37Ser
- gnomAD 20-37384263-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.419
- REVEL 0.18
- MetaLR 0.49
- MetaSVM -0.10
- CADD 23.30
- PolyPhen-2 0.97
- SIFT 0.13
- Most common in the Non-Finnish European population (allele frequency 3.7e-06)
- Structural context available
- SRC SH3 domain domainome 1.0: score -0.0639
- Literature evidence available