T37I (p.Thr37Ile) variant of SRC (P12931)
T37I (p.Thr37Ile) in SRC (P12931) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.47 / 1. The record also includes population frequency data, experimental measurements, and structural context.
T37I (p.Thr37Ile) variant details
- p.Thr37Ile
- ExAC rs769523302
- TOPMed rs769523302
- gnomAD rs769523302
- Missense
- Variant Prioritization Score for Impact Estimate 0.474
- REVEL 0.25
- CADD 25.60
- PolyPhen-2 0.99
- SIFT 0.01
- Most common in the REMAINING population (allele frequency 0.00096)
- Structural context available
- SRC SH3 domain domainome 1.0: score -0.0639