S35W (p.Ser35Trp) variant of SRC (P12931)
S35W (p.Ser35Trp) in SRC (P12931) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.37 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
S35W (p.Ser35Trp) variant details
- p.Ser35Trp
- gnomAD 20-37384257-C-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.372
- REVEL 0.25
- MetaLR 0.42
- MetaSVM -0.27
- CADD 24.20
- PolyPhen-2 0.82
- SIFT 0.01
- Most common in the Finnish in Finland (FIN) population (allele frequency 2.5e-05)
- Structural context available
- SRC SH3 domain domainome 1.0: score 0.0912
- Literature evidence available