S35L (p.Ser35Leu) variant of SRC (P12931)
S35L (p.Ser35Leu) in SRC (P12931) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.28 / 1. The record also includes population frequency data, experimental measurements, and structural context.
S35L (p.Ser35Leu) variant details
- p.Ser35Leu
- NCI-TCGA Cosmic COSV6244
- cosmic curated COSV62441
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.284
- REVEL 0.13
- CADD 19.90
- PolyPhen-2 0.08
- SIFT 0.12
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the Non-Finnish European population (allele frequency 9.1e-07)
- Structural context available
- SRC SH3 domain domainome 1.0: score 0.0912