R16L (p.Arg16Leu) variant of SRC (P12931)
R16L (p.Arg16Leu) in SRC (P12931) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.41 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
R16L (p.Arg16Leu) variant details
- p.Arg16Leu
- gnomAD 20-37384200-G-T
- Missense
- Variant Prioritization Score for Impact Estimate 0.413
- REVEL 0.22
- MetaLR 0.27
- MetaSVM -0.70
- CADD 23.00
- PolyPhen-2 0.01
- SIFT 0.07
- Population evidence available
- Structural context available
- SRC SH3 domain domainome 1.0: score -0.466
- Literature evidence available