R16H (p.Arg16His) variant of SRC (P12931)
R16H (p.Arg16His) in SRC (P12931) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.42 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R16H (p.Arg16His) variant details
- p.Arg16His
- NCI-TCGA Cosmic COSV6244
- cosmic curated COSV62441
- TOPMed rs2070409119
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.423
- REVEL 0.20
- CADD 23.30
- PolyPhen-2 0.00
- SIFT 0.22
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the South Asian population (allele frequency 2.3e-05)
- Structural context available
- SRC SH3 domain domainome 1.0: score -0.466