R15C (p.Arg15Cys) variant of SRC (P12931)
R15C (p.Arg15Cys) in SRC (P12931) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R15C (p.Arg15Cys) variant details
- p.Arg15Cys
- cosmic curated COSV62439
- Ensembl rs2147049292
- Missense
- Variant Prioritization Score for Impact Estimate 0.458
- REVEL 0.25
- CADD 23.60
- PolyPhen-2 0.13
- SIFT 0.05
- Most common in the Finnish in Finland (FIN) population (allele frequency 2.2e-05)
- Structural context available
- SRC SH3 domain domainome 1.0: score -0.372