R14W (p.Arg14Trp) variant of SRC (P12931)
R14W (p.Arg14Trp) in SRC (P12931) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.46 / 1. The record also includes population frequency data, experimental measurements, and structural context.
R14W (p.Arg14Trp) variant details
- p.Arg14Trp
- NCI-TCGA Cosmic COSV6244
- cosmic curated COSV62441
- Ensembl rs2147049257
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.459
- REVEL 0.43
- CADD 24.80
- PolyPhen-2 0.99
- SIFT 0.16
- UniProt: Variant assessed as somatic; moderate impact.
- Population evidence available
- Structural context available
- SRC SH3 domain domainome 1.0: score 0.141