L18P (p.Leu18Pro) variant of SRC (P12931)
L18P (p.Leu18Pro) in SRC (P12931) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.48 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
L18P (p.Leu18Pro) variant details
- p.Leu18Pro
- gnomAD 20-37384206-T-C
- Missense
- Variant Prioritization Score for Impact Estimate 0.483
- REVEL 0.40
- MetaLR 0.45
- MetaSVM -0.33
- CADD 26.60
- PolyPhen-2 0.99
- SIFT 0.06
- Population evidence available
- Structural context available
- SRC SH3 domain domainome 1.0: score -0.171
- Literature evidence available