F32C (p.Phe32Cys) variant of SRC (P12931)
F32C (p.Phe32Cys) in SRC (P12931) is a missense change. The available variant effect predictions contribute to a CATVariant prioritization score of 0.38 / 1. The record also includes population frequency data, experimental measurements, published literature, and structural context.
F32C (p.Phe32Cys) variant details
- p.Phe32Cys
- gnomAD 20-37384248-T-G
- Missense
- Variant Prioritization Score for Impact Estimate 0.375
- REVEL 0.26
- MetaLR 0.23
- MetaSVM -0.74
- CADD 22.50
- PolyPhen-2 0.00
- SIFT 0.03
- Most common in the Non-Finnish European population (allele frequency 1.8e-06)
- Structural context available
- SRC SH3 domain domainome 1.0: score -0.158
- Literature evidence available