F59L (p.Phe59Leu) variant of SPINK5 (Q9NQ38)
F59L (p.Phe59Leu) in SPINK5 (Q9NQ38) is a missense change. Clinical records from UniProt describe it as variant assessed as somatic; moderate impact. The available variant effect predictions contribute to a CATVariant prioritization score of 0.25 / 1. The record also includes population frequency data and structural context.
F59L (p.Phe59Leu) variant details
- p.Phe59Leu
- NCI-TCGA Cosmic COSV5626
- cosmic curated COSV56261
- Variant assessed as somatic; moderate impact.
- Missense
- Variant Prioritization Score for Impact Estimate 0.252
- REVEL 0.04
- MetaLR 0.02
- MetaSVM -1.00
- CADD 13.60
- PolyPhen-2 0.01
- SIFT 0.39
- UniProt: Variant assessed as somatic; moderate impact.
- Most common in the 1KG:CLM population (allele frequency 0.0053)
- Structural context available